There are those who will always do better with more traditional treatments. This is also known as Online Behavioural Advertising. Because it turns out I have a genetic mutation on one of my genes, one with the rather apt acronym MTHFR. Broadly, nutrigenetics looks at how human genetic variation results in distinct nutritional requirements, and how diet and nutrition modulate the expression of genes. CSIRO principal research scientist, Professor Michael Fenech — who leads the genome health and nutrigenomics project — first started looking at MTHFR because of the C677T’s association with increases in homocysteine, which has also been linked with an increased risk of DNA damage, cardiovascular disease and Alzheimer’s disease. That, in turn, can lead to a Pandora’s Box of health problems.

An article in the journal Biology and Medicine last year looked at the clinical implications of MTHFR mutations in disease, and certain cancers in particular. The reduction of my own migraines has been a happy side effect of treating my anxiety with folinic acid and B12. My anxiety is a wild beast. Truth-be-told, Mum’s side of the family is littered with us crazy types, all of us muddling along as best we can, desperately trying to look normal while we indulge in the various routines, compulsions and obsessions that help us feel like we have some kind of control over our anxiety or depression. I felt better than I had ever felt  before – full of energy, clear-headed, depression and anxiety-free.

I feel like it’s given me a new life and made it a hell of a lot easier to get out of bed.”.

Adamski believes a reluctance on the part of many GPs to invest more time in nutrigenetic testing is because there are no best-practice guidelines for them to look to. Professor Fenech says while thousands of papers have been published globally on the association of MTHFR polymorphisms with the risk of diseases of old age as well as pregnancy complications, having a baby with Down syndrome or with neural tube defects, relatively few papers have been published on the effect of MTHFR variations on many other aspects of health in Australia. And those patients don’t only include those with anxiety or depression.

Six months ago I discovered my methylenetetrahydrofolate reductase gene, known broadly (and aptly) as MTHFR, is a bit wonky.

This time, I asked for a vitamin D3 test to be included. And supplementing has made the BIGGEST difference in how I feel, hands down. * Folinic acid is available from pharmacies in Australia on prescription. I also take vitamin D3 and it's very helpful for many things, but not a cure for my fatigue. If you enjoyed this post, make sure you Subscribe here for free and receive your FREE eBook “1 Week to a Happier You”. Post was not sent - check your email addresses! The distinction between folinic acid* and the common dietary vitamin, B9 or folic acid, is an important one.

“I’d been on medication for many years, felt tired all the time, I was eating well but not losing weight, I had no enthusiasm for life.”. Enjoy this informative post on the MTHFR genetic defect […] How a vitamin cured my anxiety: Elisa Black’s story of lifelong struggle and new hope for the future. This is a chemical found in a metabolic cycle called methylation that relies heavily on B-vitamins and plays an important role in, among many other things, mood regulation. That my anxiety has a genetic link is, on reflection, no great surprise to me.

Griffiths is hoping results from Phase 3 studies will replicate what has been found in the previous two — that the C677T mutation occurs more often in people with migraine and migraine with aura and that a combination of B-group vitamins can drop homocysteine and significantly reduce frequency, severity and pain. A 2011 study reported a possible link between a different MTHFR variation and ADHD. “But 70 per cent of our MTHFR patients present with anxiety.” Depression is also a very big component she adds, explaining that folate is important to the processes that produce key brain chemicals like serotonin, dopamine and melatonin. My maternal grandfather had what was then known as a “nervous breakdown” and was prone to bouts of melancholy. Vitamin D is a hormone that’s connected to almost every system in the body. Response times can vary.

At present there is a great need for understanding the condition and a greater need for its management”. I’ve doggedly practised yoga, meditated morning and night, exercised feverishly to try and get rid of the adrenalin coursing through my veins. Variations in the MTHFR gene mean I am unable to convert folic acid into a form my body can use — folinic acid — easily. I still have my moments and suspect my anxiety is not only caused by a MTHFR mutation but by a combination of personality, learned behaviours, an obsession with medical-reality TV shows and an incorrigible tendency towards fantastical thinking. The genetic mutation also affects close to one in five people and could be responsible for everything from mood disorder or multiple miscarriages to strokes, cardiovascular disease, diabetes and many other illnesses. I still sometimes obsess about whether my kids have some deadly tropical disease. I only wish I had known about it sooner! Can we stop multiple miscarriages?

My maternal grandmother would suffer from constant nervous attacks that would leave her feeling “oomi”, forcing her to rely heavily on Valium in a time when mental health was neither discussed nor publicly acknowledged. “I felt a change within a month,” she says. I swear it feels like it made me smarter, raised my I.Q, ha.

I’ve met people with a double copy of the genetic variation who haven’t had much in the way of symptoms.

Hello: I suffered from depression, anxiety, and panic disorder for a few decades.

She adds that many people don’t actually want to know what secrets may be hiding in their genes, often because they don’t understand that, while genes can’t be changed, their expression sometimes can. “After a few of my patients responded dramatically I thought this could be something to use on those who didn’t respond to SSRIs (a type of antidepressant).”.

So if there is a possibility that these common mental disorders could be improved by the addition of a readily available vitamin, why are more general practitioners not testing their patients? Log in, How a vitamin cured my anxiety: Elisa Black’s story of lifelong struggle and new hope for the future. Vitamin D: I talk a ton about how important sunlight is for mental heath. Studies have shown homocysteine levels can predict the length someone might suffer from post-traumatic stress disorder, that B vitamins have been observed to relieve premenstrual anxiety, and that MTHFR variations are associated with major depression, bipolar disorder and schizophrenia.

“We don’t have a lot of best-practice guidelines on how to use genetic information,’’ she says. I could not be convinced that I was safe.

SAMe is required for neurotransmitter synthesis which is important for proper nerve and brain function. I can still experience anxiety.

If only I’d known that something as simple — and free of side effects — as B vitamins was a credible option before I spent all my money on enough hand sanitiser to keep all the world’s bacteria at bay. Zinc supplementation has been shown to reduce symptoms of anxiety . Naturopath Carolyn Ledowsky is the founder of MTHFR Support Australia.

“Misinformation needs to be cleared up — giving people clear examples of what they can change nutritionally to help them.

“When this is addressed and B12 and folate levels are restored, anxiety will be decreased by about 80 per cent within three weeks or so. But I would say that this has made a 95% difference in how I feel. In addition to more vitamin D and B12, she started taking magnesium, turmeric, vitamin D3, serenol (for PMS), and omega-3s.

Vitamin d cured my anxiety and depression.

I first discovered the wonders of vitamin d over 2 years ago.

We need to get away from the thinking that genetic testing will just show what things will definitely happen to them and start to understand that it can start to guide preventive health recommendations and treatment options.”. Since starting folinic acid and B12 six months ago, I have had no migraines.

But, like so much in medicine, the effects of the treatment aren’t utterly predictable. The result is that my body has trouble processing B-group vitamins.

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